Possible side-effects: BI 690517 or matching placebo
BI 690517 10mg or matching placebo pills may increase the levels of potassium (a mineral) and affect the level of the stress hormone, cortisol, in your blood.
Your potassium levels will be checked at each study appointment and participants with high potassium may be asked to modify their diet by their local team. Modifying amounts of potassium in the diet is a common practice that patients with kidney disease are asked to follow. We have provided you with an additional Dietary Potassium Leaflet, in case you
should ever be requested to modify the amount of potassium in your diet.
We will be monitoring your stress hormone, cortisol, levels because BI 690517 could affect your blood cortisol levels. Your blood cortisol levels normally fluctuate throughout the day so will need to be specifically measured in the early morning (ideally before 09:00) at two points in the trial: the one month and three-month follow-up visits (and also if your local doctor requests it).
BI 690517 and the empagliflozin pills may lower your blood pressure. If you feel light-headed or dizzy on standing, please inform your local study nurse or the EASi-KIDNEYTM office. We can arrange for you to see your local study nurse in the next few days for a review where necessary.